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Indications and Dosage
Topical/Cutaneous
Prophylaxis of gonococcal ophthalmia neonatorum Child: Neonate: As a 1% solution: To be applied after cleansing of the neonate's eyes immediately after birth. Topical/Cutaneous Antiseptic agent Adult: As a 0.5% solution: May be applied to severe burns to reduce risk of infection.
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Contraindications
Hypersensitivity. Applicator sticks not for ophthalmic use.
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Special Precautions
Prolonged use may result to skin discolouration. Protect surrounding skin and avoid broken skin. Not suitable for application to face, ano-genital region or large areas.
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Adverse Reactions
Pain in the mouth, sialorrhoea, diarrhoea, vomiting, coma and convulsions. Argyria (chronic use); methaemoglobinaemia; electrolyte disturbances. Short-term mild conjunctivitis in infants which may lead to blindness if use repeatedly or with high concentrations.
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Action
Description: Silver nitrate inhibits growth of both gram-positive and gram-negative bacteria by precipitating bacterial protein through the release of liberated silver ions. It also forms an eschar by coagulation of cellular proteins.
Pharmacokinetics: Absorption: Minimal GI and cutaneous absorption because of the readiness of silver ions to combine with protein. |
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Storage
Topical/Cutaneous:
Prophylaxis of gonococcal ophthalmia neonatorum: Store in a tight, light-resistant container. Exposure to light causes silver to oxidise and turn brown. |
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MIMS Class
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